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Anti-EphA4-calicheamicin ADC (CAT#: ADC-114LZY)

This ADC product is composed of an anti-EphA4 antibody conjugated via linker to calicheamicin (anti-EphA4-calicheamicin). It is in Phase I clinical trials and has demonstrated a response in Solid tumor treatment by a MOA (Mechanism of Action) of binding to DNA minor groove and causing sequence-specific double-strand DNA cleavage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 Cerebral cortex
Figure 1 Cerebral cortex
(Neuropil
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_B_7_5.jpg
Figure 2 Cerebellum
Figure 2 Cerebellum
(Molecular layer - neuropil
Staining:Medium
Intensity: Moderate
Molecular layer cells - cytoplasm/membrane
Staining:High
Intensity: Strong
Synaptic glomeruli - capsule
Staining:Medium
Intensity: Moderate
Synaptic glomeruli - core
Staining:Medium
Intensity: Moderate)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_B_8_8.jpg
Figure 3 Colon
Figure 3 Colon
(Enterocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_9_3.jpg
Figure 4 Kidney
Figure 4 Kidney
(Proximal tubules (cell body)
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_9_5.jpg
Figure 5 Testis
Figure 5 Testis
(Elongated or late spermatids
Staining:Medium
Intensity: Moderate
Quantity:>75%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28368/71560_A_5_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, ASC diff, CACO-2, U-2197)
Figure 6 RNA cell line category: Cell line enhanced (AF22, ASC diff, CACO-2, U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000116106-EPHA4

Specifications

  • Antibody Overview
  • Anti-EphA4 Antibody
  • Drug
  • calicheamicin
  • Drug Class/Description
  • Class: Calicheamicin
    Description: Calicheamicin, produced by prokaryotic microorganisms, are a group of DNA cleaving agents with similar structure that binds in the minor grove of DNA in a relatively sequence-specific manner.

Target

  • Introduction
  • This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • EPHA4; EPH receptor A4; SEK; HEK8; TYRO1; ephrin type-A receptor 4; EK8; EPH-like kinase 8; TYRO1 protein tyrosine kinase; tyrosine-protein kinase TYRO1; tyrosine-protein kinase receptor SEK; receptor protein-tyrosine kinase HEK8;

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See other products for "EPHA4"

Human Antibody

CAT Product Name Application Type
TAB-386MZ Anti-Human EPHA4 Recombinant Antibody (65) Cyt Human antibody
TAB-387MZ Anti-Human EPHA4 Recombinant Antibody (336) Cyt Human antibody
TAB-386MZ-S(P) Anti-Human EPHA4 Recombinant Antibody scFv Fragment (65) FC Human antibody
TAB-387MZ-S(P) Anti-Human EPHA4 Recombinant Antibody scFv Fragment (336) FC Human antibody
TAB-386MZ-F(E) Anti-Human EPHA4 Recombinant Antibody Fab Fragment (65) FC Human antibody

Mouse Antibody

CAT Product Name Application Type
TAB-388MZ Anti-Human EPHA4 Recombinant Antibody (EphA4-44/EA44) ELISA
TAB-388MZ-S(P) Anti-Human EPHA4 Recombinant Antibody scFv Fragment (EphA4-44/EA44) ELISA
TAB-388MZ-F(E) Anti-Human EPHA4 Recombinant Antibody Fab Fragment (EphA4-44/EA44) ELISA

Recombinant Antibody

CAT Product Name Application Type
MOB-0652CT Recombinant Mouse anti-Human EPHA4 Monoclonal antibody (EML064) WB
HPAB-0004-DJB Human Anti-EPHA4 Recombinant Antibody (HPAB-0004-DJB) ELISA, Block Human IgG1
HPAB-0005-DJB Human Anti-EPHA4 Recombinant Antibody (HPAB-0005-DJB) ELISA, Block Human IgG1
HPAB-0156-FY Human Anti-EPHA4 Recombinant Antibody (clone SC4.15) Inhib Humanized IgG1, κ
VS-0723-WK99 Human Anti-EPHA4 Recombinant Antibody (VS-0723-WK99) FC Chimeric (rabbit/human) IgG1

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0004-DJB-S(P) Human Anti-EPHA4 Recombinant Antibody; scFv Fragment (HPAB-0004-DJB-S(P)) ELISA, Block Human scFv
HPAB-0005-DJB-S(P) Human Anti-EPHA4 Recombinant Antibody; scFv Fragment (HPAB-0005-DJB-S(P)) ELISA, Block Human scFv
HPAB-0006-DJB-S(P) Human Anti-EPHA4 Recombinant Antibody (clone m119); scFv Fragment ELISA, Block Human scFv
HPAB-0156-FY-S(P) Human Anti-EPHA4 Recombinant Antibody (clone SC4.15); scFv Fragment Inhib Humanized scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0004-DJB-F(E) Human Anti-EPHA4 Recombinant Antibody; Fab Fragment (HPAB-0004-DJB-F(E)) ELISA, Block Human Fab
HPAB-0005-DJB-F(E) Human Anti-EPHA4 Recombinant Antibody; Fab Fragment (HPAB-0005-DJB-F(E)) ELISA, Block Human Fab
HPAB-0006-DJB-F(E) Human Anti-EPHA4 Recombinant Antibody (clone m119); Fab Fragment ELISA, Block Human Fab
HPAB-0156-FY-F(E) Human Anti-EPHA4 Recombinant Antibody (clone SC4.15); Fab Fragment Inhib Humanized Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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