Anti-FRα-DGN462 ADC (CAT#: ADC-120LZY)

This ADC product is composed of an anti-FRα antibody conjugated via linker to DGN462 (anti-FRαSeriMab-DGN462). It has demonstrated a response in non-small cell lung cancer treatment by a MOA (Mechanism of Action) of binding to DNA minor groove and causing sequence-specific double-strand DNA cleavage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Antibody Overview
  • Anti-FRαSeriMab (SeriMab:N-terminal serine engineered Antibody)
  • Antibody Conjugation
  • site-specific conjugation platform employs N-terminal serine engineered antibodies (SeriMabs), using ligation chemistry orthogonal to lysine and cysteine modification which typically employs maleimide containing linkers
  • Linker
  • maleimide containing linkers
  • Drug
  • DGN462
  • Drug Class/Description
  • Class: DGN462
    Description: DGN462,the mono-imine IGN, highly potent cytotoxic DNA alkylateing agent.DGN462 formed covalent DNA adducts through alkylation of the C2-amino group of guanine.

Target

  • Introduction
  • The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
  • Alternative Names
  • FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18;

Downloads

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Intrabody

CAT Product Name Application Type
IAB-B029(A) Recombinant Anti-human FOLR1 Intrabody [(D-Arg)9] PCA, Neut, FuncS scFv-(D-Arg)9
IAB-B029(G) Recombinant Anti-human FOLR1 Intrabody [+36 GFP] WB, Neut, FuncS scFv-(+36GFP)
IAB-B029(T) Recombinant Anti-human FOLR1 Intrabody [Tat] WB, ICC, Neut, FuncS scFv-Tat

Humanized Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-018CQ Human Anti-FOLR1 Recombinant Antibody (TAB-018CQ) ELISA, WB, IHC Chimeric (Rat/Human) IgG1, κ
TAB-018CQ-S(P) Human Anti-FOLR1 Recombinant Antibody; scFv Fragment (TAB-018CQ-S(P)) ELISA, WB, IHC Human scFv
TAB-018CQ-F(E) Human Anti-FOLR1 Recombinant Antibody; Fab Fragment (TAB-018CQ-F(E)) ELISA, WB, IHC Chimeric (Rat/Human) Fab

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-029LC-1 Recombinant Anti-Human FOLR1 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1333 Hi-Affi™ Rabbit Anti-FOLR1 Recombinant Antibody (clone DS1333AB) WB Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-113 Afuco™ Anti-FOLR1 ADCC Recombinant Antibody (Farletuzumab), ADCC Enhanced FC, IP, ELISA, Neut, FuncS, IF ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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