Anti-Robo4-SPDB-DM4 ADC (CAT#: ADC-267CL)
This ADC product is composed of an anti-Robo4 antibody conjugated via SPDB linker to DM4(anti-Robo4-SPDB-DM4). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line PC-3
(Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
(Immunofluorescent staining of human cell line PC-3 shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/65212/1589_F7_2_selected.jpg
Figure 2 RNA cell line category: Group enriched (HUVEC TERT2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154133-ROBO4
Specifications
- Antibody Overview
- Anti-Robo4 Antibody,
- Linker
- SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate)
- Linker Class/Description
- Class: Chemically cleavable linkers-Disulfide Linkers
Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- ROBO4 (Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila)) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling. GO annotations related to this gene include receptor activity.
- Alternative Names
- ROBO4; roundabout, axon guidance receptor, homolog 4 (Drosophila); MRB; ECSM4; roundabout homolog 4; roundabout homolog 4, magic roundabout;
- Gene ID
- 54538
- UniProt ID
- B4DYV8
Downloads
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Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-329CT | Mouse Anti-Robo4 Recombinant Antibody (TAB-329CT) | WB, ELISA, FC, IHC | Mouse IgG2a |
| TAB-329CT-S(P) | Mouse Anti-Robo4 Recombinant Antibody; scFv Fragment (TAB-329CT-S(P)) | WB, ELISA, FC, IHC | Mouse scFv |
| TAB-329CT-F(E) | Mouse Anti-Robo4 Recombinant Antibody; Fab Fragment (TAB-329CT-F(E)) | WB, ELISA, FC, IHC | Mouse Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-330CT | Anti-Human Robo4 Recombinant Antibody (YW79.11) | WB, ELISA, FC | Human antibody |
| TAB-330CT-S(P) | Anti-Human Robo4 Recombinant Antibody scFv Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
| TAB-330CT-F(E) | Anti-Human Robo4 Recombinant Antibody Fab Fragment (YW79.11) | WB, ELISA, FC | Human antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4396 | Hi-Affi™ Recombinant Rabbit Anti-ROBO4 Monoclonal Antibody (SI487DS) | ELISA | IgG |
Neuroscience Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-076CN | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22) | FC, ELISA, FuncS | Human IgG |
| NS-076CN-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); Fab Fragment | FC, ELISA | Human Fab |
| NS-076CN-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.22); scFv Fragment | FC, ELISA | Human scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ | Human Anti-ROBO4 Recombinant Antibody (HPAB-0045-WJ) | ELISA, RIA | Humanized IgG2, κ |
| HPAB-N0234-YC | Human Anti-ROBO4 Recombinant Antibody (HPAB-N0234-YC) | FC, Activ | Humanized (mouse/human) IgG |
| HPAB-J0217-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6) | ELISA | Human IgG |
| HPAB-J0218-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW71.1) | ELISA | Human IgG |
| HPAB-J0219-YC | Human Anti-ROBO4 Recombinant Antibody (clone YW79.1) | ELISA | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0045-WJ-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-0045-WJ-F(E)) | ELISA, RIA | Humanized Fab |
| HPAB-N0234-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody; Fab Fragment (HPAB-N0234-YC-F(E)) | FC, Activ | Humanized (mouse/human) Fab |
| HPAB-AP412-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-AP413-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); Fab Fragment | ELISA, FC | Chimeric (mouse/human) Fab |
| HPAB-J0217-YC-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); Fab Fragment | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP412-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-1); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-AP413-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone cMAb1-2); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-J0217-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.6); scFv Fragment | ELISA | Human scFv |
| HPAB-J0218-YC-S(P) | Human Anti-ROBO4 Recombinant Antibody (clone YW71.1); scFv Fragment | ELISA | Human scFv |
| HPAB-1902-FY-F(E) | Human Anti-ROBO4 Recombinant Antibody (clone MR7); scFv Fragment | ELISA, Inhib | Human scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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