Anti-TPBG-mc-MMAF ADC (CAT#: ADC-094LZY)

This ADC product is composed of an anti-TPBG antibody conjugated via mc linker to MMAF (anti-TPBG-mc-MMAF). It has demonstrated a response in lung and breast tumor treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-TPBG Humanized
    IgG1 mAb,A1
  • Antibody Isotype
  • IgG1
  • Linker
  • mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • MMAF(monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5 UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
  • Alternative Names
  • TPBG; trophoblast glycoprotein; 5T4; M6P1; 5T4AG; WAIF1; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; wnt-activated inhibitory factor 1; 5T4 oncofetal trophoblast glycoprotein;

Downloads

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Mouse Antibody

CAT Product Name Application Type
TAB-118-F(E) Anti-Human 5T4 Recombinant Antibody Fab Fragment, 5T4 (Naptumomab Estafenatox) FuncS, IF, Neut, ELISA, FC, IP, ICC Fab - G1 - kappa

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3649 Rabbit Anti-TPBG Recombinant Antibody (clone DS3649AB) WB, ICC, IP Rabbit IgG

Recombinant Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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