Anti-VEGFR2 ScFv-As2O3-nanoparticles ADC (CAT#: ADC-172LCT)

This ADC product is composed of an anti-VEGFR2 scFv conjuagated to As2O3-nanoparticles (anti-VEGFR2 ScFv-As2O3-nanoparticles). It has demonstrated a response in Hepatocellular carcinomas (HCC) treatment by a MOA (Mechanism of Action) of significantly inhibit angiogenesis.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Anti-VEGFR2 ScFv
  • Clone
  • anti-VEGFR2 ScFv
  • Drug
  • As2O3-nanoparticles
  • Drug Class/Description
  • Arsenic trioxide is an inorganic compound with the formula As
    2O
    3. This commercially important oxide of arsenic is the main precursor to other arsenic compounds, including organoarsenic compounds. Approximately 50,000 tonnes are produced annually.[4] Many applications are controversial given the high toxicity of arsenic compounds.

Target

  • Introduction
  • Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
  • Alternative Names
  • KDR; kinase insert domain receptor; FLK1; CD309; VEGFR; VEGFR2; vascular endothelial growth factor receptor 2; soluble VEGFR2; fetal liver kinase 1; fetal liver kinase-1; protein-tyrosine kinase receptor Flk-1; tyrosine kinase growth factor receptor; kinase insert domain receptor (a type III receptor tyrosine kinase);

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Intrabody

CAT Product Name Application Type
IAB-B066(A) Recombinant Anti-human KDR Intrabody [(D-Arg)9] FC, IF, FuncS scFv-(D-Arg)9
IAB-B066(G) Recombinant Anti-human KDR Intrabody [+36 GFP] CO-IP, FuncS scFv-(+36GFP)
IAB-B066(T) Recombinant Anti-human KDR Intrabody [Tat] IF, ELISA, FuncS scFv-Tat

Humanized Antibody

CAT Product Name Application Type
TAB-202 Humanized Anti-KDR Recombinant Antibody (clone Alacizumab); di - Fab' Fragment IF, IP, Neut, FuncS, ELISA, FC, ICC Humanized (from mouse) di - Fab'
TAB-411CQ Anti-Human KDR Recombinant Antibody (HLX06) ELISA Humanized antibody
TAB-411CQ-S(P) Anti-Human KDR Recombinant Antibody scFv Fragment (HLX06) ELISA Humanized antibody
TAB-411CQ-F(E) Anti-Human KDR Recombinant Antibody Fab Fragment (HLX06) ELISA Humanized antibody

Immunotoxin

CAT Product Name Application Type
AGTO-G047E Anti-KDR immunotoxin (IgG1)-PE Cytotoxicity assay, Function study

Human Antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0624MZ Chicken Anti-VEGFR-2 Polyclonal IgY IHC, WB Chicken antibody
BRD-0709MZ Chicken Anti-KDR Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-079 Afuco™ Anti-KDR ADCC Recombinant Antibody (Ramucirumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

Single-domain Antibody

CAT Product Name Application Type
HPAB-0298-YJ-VHH Recombinant Human Anti-KDR Nano Antibody (NTV1) Inhib Human VHH

MHC Tetramer for Cancer

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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