Anti-gp120-mc-vc-PABC-MMAE ADC (CAT#: ADC-207LZY)
This ADC product is composed of an anti-gp120 antibody conjugated via mc-vc-PABC linker to MMAE (anti-gp120-mc-vc-PABC-MMAE). It has demonstrated a response in human immunodeficiency virus type 1 (HIV-1) treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Specific Inquiry
Specifications
- Antibody Overview
- Mouse Anti-gp120 IgG1
- Antibody Isotype
- IgG1
- Linker
- mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- HIV1 is equipped with the envelope gp160 glycoprotein for interaction with Langerhans cells (LCs) and dendritic cells (DCs), the members of the innate immune system, which confront the virus at the portal of virus entry in the human body. These cells are equipped with receptors by which they bind and endocytose the virus. The gp120 glycoprotein is used for binding to CD4 receptor and CCR5 co-receptor of T helper 2 (Th2) cells, and is able to induce FcepsilonRI(+) hematopoietic cells to produce IL4, which inactivates the host adaptive immune response.
- Alternative Names
- ENV; gp160; envelope glycoprotein; Envelope surface glycoprotein gp160, precursor; hypothetical protein; Envelope surface glycoprotein gp120; Envelope transmembrane domain
Downloads
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-062 | Recombinant Human Anti-gp120 Antibody (PGT121-GL) | WB, ELISA, FuncS | IgG |
| PABX-062-F (E) | Recombinant Human Anti-gp120 Antibody Fab Fragment (PGT121-GL) | WB, ELISA, FuncS | Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-062-S (P) | Recombinant Human Anti-gp120 Antibody scFv Fragment (PGT121-GL) | WB, ELISA, FuncS | scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-002-VHH | Recombinant Anti-HIV-1 gp120 VHH Single Domain Antibody (A12) | ELISA | llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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