Anti-Human ITGAV Recombinant Antibody (Abituzumab) (CAT#: TAB-H01)

Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Block

Figure 1 Abituzumab Blocks Elevated Expression of FMT-Related Genes in H358-Fibroblast Co-cultures.

Figure 1 Abituzumab Blocks Elevated Expression of FMT-Related Genes in H358-Fibroblast Co-cultures.

Block

Figure 2 Inhibition of Abituzumab to FMT-Related genes expression in H358-Fibroblast co-cultures.

Figure 2 Inhibition of Abituzumab to FMT-Related genes expression in H358-Fibroblast co-cultures.

Inhib

Figure 3 Inhibition of ανβ6 6 binding to LAP by Abituzumab in comparison to anti-HEL-AB MSB0011523H-1 and 10D5, respectively

Figure 3 Inhibition of ανβ6 6 binding to LAP by Abituzumab in comparison to anti-HEL-AB MSB0011523H-1 and 10D5, respectively

Agonist

Figure 4 DI17E6 promotes detachment of prostate cancer cells from vitronectin.

Figure 4 DI17E6 promotes detachment of prostate cancer cells from vitronectin.

Prostate cancer cell lines (LNCaP, C4-2B, ARCaP, PC3, DU145 and VCaP cells) were seeded on 96-well plates coated with vitronectin.

Jiang, Y. , Dai, J. , Yao, Z. , Shelley, G. , & Keller, E. T. . (2017). Abituzumab targeting of αv-class integrins inhibits prostate cancer progression. molecular cancer research mcr, 15(7), molcanres.0447.2016.

Inhib

Figure 5 DI17E6 inhibits adhesion of prostate cancer cells on vitronectin.

Figure 5 DI17E6 inhibits adhesion of prostate cancer cells on vitronectin.

Prostate cancer cell lines (LNCaP, C4-2B, ARCaP, PC3, DU145 and VCaP cells) were seeded on the 96-well plates pre-coated with fibronectin.

Jiang, Y. , Dai, J. , Yao, Z. , Shelley, G. , & Keller, E. T. . (2017). Abituzumab targeting of αv-class integrins inhibits prostate cancer progression. molecular cancer research mcr, 15(7), molcanres.0447.2016.


Specifications

  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG2 - kappa
  • Specificity
  • ITGAV (integrin alpha V, CD51) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • Inhib, Agonist
  • CAS
  • 1105038-73-0
  • Generic Name
  • abituzumab
  • Related Disease
  • Colorectal cancers, metastatic

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.

Applications

  • Application Notes
  • The Human ITGAV antibody has been reported in applications of Inhibition, Agonist.

Target

  • Alternative Names
  • abituzumab;1105038-73-0;EMD525797;EMD 525797;DI-17E6;DI17E6;ITGAV;integrin, alpha V;antigen identified by monoclonal L230 , integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) , MSK8, vitronectin receptor , VNRA, VTNR;integrin alpha-

Related Resources

  • Biosimilar Overview
Please refer to Abituzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Abituzumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Abituzumab"

Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Humanized (from mouse) antibody to Human ITGAV. Abituzumab (EMD 525797)is a humanised monoclonal antibody targeting integrin αν heterodimers.

See other products for "ITGAV"

Human Antibody

CAT Product Name Application Type
TAB-076 Anti-Human CD51 Recombinant Antibody (Intetumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Blocking Antibody

CAT Product Name Application Type
NEUT-1537CQ Recombinant Mouse Anti-ITGAV Antibody (272-17E6) Inhib, ICC/IF, BL, FC, ELISA, IP IgG1
NEUT-1577CQ Recombinant Mouse Anti-ITGAV Antibody (13C2) FC, IHC-Fr, ICC, IP, ELISA, Depletion, BL, Adhesion IgG1, κ
NEUT-1578CQ Recombinant Mouse Anti-ITGAV Antibody (NKI-M9) FC, IF, ELISA, BL, IP IgG2a, κ
NEUT-1579CQ Recombinant Mouse Anti-ITGAV Antibody (10D5) IP, FC, BL IgG2a
NEUT-1580CQ Recombinant Mouse Anti-ITGAV Antibody (27.1) ICC/IF, FC, IP, IHC-Fr, BL IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-1582CQ Recombinant Rat Anti-Itgav Antibody (RMV-7) FC, FuncS, IP, Neut IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-076 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Intetumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-H01 Afuco™ Anti-ITGAV ADCC Recombinant Antibody (Abituzumab), ADCC Enhanced ELISA, IP, FC, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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