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Bispecific Antibody Fagments (BsAb Fragments)


Creative Biolabs possesses unchallenged experience in antibody development and recombinant protein synthesis. Multiple platforms of Creative Biolabs are elaborately integrated for providing customers one-stop services for BsAb fragments development. Our cutting-edge techniques promise our BsAb products with not only high affinity and multiple valences to different targets, but also reliable safety for both academic and clinical applications.


Figure: BsAb fragment family (Immunology, 2015)

Bispecific antibodies (BsAbs) are artificial antibodies which possess two distinct specificities. Thereby, it is able to recognize two different antigens or epitopes simultaneously. Taking advantage of this unique character, researchers use BsAbs to guide effectors to targets of interest for further cellular or physiological effects, such as triggering the contacts between immune cells and tumor cells by binding marker proteins on the surface of each cell type simultaneously.

After years of development, the first BsAb drug was approved in 2009 and another entered the market in 2014. Meanwhile, more candidates are in clinical trials. Its outstanding therapeutic effect promises a bright future in both merchant benefit and social concern.

As a leading immune research service provider, Creative Biolabs is committed to providing customers the most comprehensive list of BsAb fragments products in the market. Classified by their size and backbone utilized, Our BsAb fragment products include: Bi-single domain antibody, DART, TandAb, BiTE, Tandem scFv-Fc BsAb, Diabody, Triplebody, Mini-antibody, Minibody, scFv fragments BsAb, Fab fragments BsAb, scFv-Fab fragments BsAb, Bispecific intrabody and Tetravalent hcAb.


Highlighted by the recombinant antibody synthesis platform, multiple bio-engineering platforms in Creative Biolabs are integrated as a budget and time-saving working procedure. Creative Biolabs is committed to providing BsAb fragment products targeting any pair of antigens of interest with experimentally verified high-affinity. As a global company, Creative Biolabs would like to share all its talented and well-trained scientists to support your development of medicines for the future.

We can generate different classes of bispecific antibodies, which include:

  1. Bispecific IgGs
  2. Appended IgGs 
  3. Bispecific antibody fragments
  4. Bispecific fusion proteins
  5. Bispecific antibody conjugates

Christoph Spiess, et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Molecular Immunology 2015, 67, 95–106.

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