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Bispecific Fusion Proteins

Creative Biolabs offers our expertise in constructing bispecific fusion proteins for your research and development purposes. We work closely with our customers so as to design every project according to their individual requirements.

Figure: Schematic representation of the Bispecific Fusion Proteins (Mol Immunol, 2015)

Bispecific fusion protein is a major bispecific antibody format, which has been explored as a pre-targeting strategy for imaging and radioimmunotherapy. It is generated by linking antibody fragments to other proteins to achieve additional function or specificity. The source of antibody fragments can be derived from scFv or monospecific Fab dimer. The linker protein can be specific receptors of lymph cells (such as T cell, B cell or macrophage); a second Fab molecule; or a strong and specific ligand of a receptor on tumor cells. Besides that, human serum albumin or albumin binding proteins can also be fused with antibody fragments to extend their serum half-life in vivo. We offer our client many different types of bispecific fusion proteins including:

  1. DNL BsAb
  2. ImmTACs
  3. HSAbody
  4. Tandem scFv-Toxin BsAb

Creative Biolabs has strong expertise in bispecific antibody construction, which endues us with genreating diverse forms of bispecific fusion proteins without any extra increase in cost. With our most devoted scientists, we are confident to deliver you a bispecific fusion protein that can meet all of your required specifications.

We can generate different classes of bispecific antibodies, which include:

  1. Bispecific IgGs
  2. Appended IgGs 
  3. Bispecific antibody fragments
  4. Bispecific fusion proteins
  5. Bispecific antibody conjugates

Christoph Spiess, et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol. 2015 Oct; 67(2 Pt A):95-106.

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