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Bispecific Intrabody

Creative Biolabs possesses unchallenged experience in synthesis of bispecific intrabodies. Our elaborately integrated multiple platforms can provide customers an expected bispecific intrabody with high affinity and low immunogenicity for both academic and clinical applications.


Figure: Diagram of Bispecific intrabody structure

Besides the chain paring problem, the affinity and valence of a BsAb to its targets also have an effect on its application potential. Thus, bispecific intrabody is developed to overcome these issues. A bispecific intrabody has two identical immunoglubin chains paired via its recombinant Fc domains. Meanwhile, two pairs of single chain Fvs (scFvs) with distinct specificity are linked to each end of the Fc domain respectively. Since the component unit for dimerization is uniform, this strategy significantly simplifies the generation process of bispecific products. Furthermore, as each component unit is bispecific and bivalence, the homodimer product is not only bispecific but also tetravalence. These properties make bispecific intrabody a leading candidate format for both drug development and academic research.

Based on our multiple antibody bio-engineering platforms, Creative Biolabs can design a budget and time-saving working procedure for customers in order to provide them desired bispecific intrabodies with experimentally verified high-affinity.

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