Anti-CD30 (clone cAC10)-vc-MMAE ADC (CAT#: ADC-024LZY)

This ADC product is composed of an anti-CD30 antibody (clone cAC10) conjugated via vc linker to MMAE (cAC10-vc-MMAE). It has demonstrated a response in Hodgkin lymphoma (HL) and anaplastic large cell lymphoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Chimeric Anti-CD30 mAb,cAC10
  • Clone
  • cAC10
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30;

Downloads

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Human Antibody

CAT Product Name Application Type
TAB-144 Anti-Human CD30 Recombinant Antibody (Iratumumab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa

Chimeric Antibody

CAT Product Name Application Type
TAB-153 Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (clone Brentuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC Human IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-G062E Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE Cytotoxicity assay, Function study
AGTO-G062R Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA Cytotoxicity assay, Function study
AGTO-G062S Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap Cytotoxicity assay, Function study
AGTO-L041R anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L041S anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-Sap Cytotoxicity assay, Functional assay

Humanized Antibody

Fc Glycosylation

CAT Product Name Application Type
Gly-139LC Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Low- or Non-fucosylated Oligosaccharide

CAT Product Name Application Type
Gly-139LC-1 Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated) ELISA Human antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0597MZ Chicken Anti-TNFRSF8 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-2165CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1) FC, Stim, Costim, Block Hamster IgG1

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2166CQ Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F) Neut, FC Hamster IgG1, κ

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-144 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Iratumumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody
AFC-TAB-153 Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody (Brentuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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