Anti-B7H4 (clone h1D11)-vc-PABC-MMAE ADC (CAT#: ADC-061LZY)

This ADC product is composed of an anti-B7H4 antibody (clone h1D11) conjugated via vc-PABC linker to MMAE (h1D11-vc-PABC-MMAE). It has demonstrated a response in breast cance treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized Anti-B7H4 mAb, h1D11
  • Clone
  • h1D11
  • Antibody Conjugation
  • an engineered cysteine residue that replaces
    alanine at position 114 (Kabat numbering) of the heavy chain
    constant region of the antibody
  • Linker
  • VC-PABC(valine-citrulline-p-aminobenzylcarbamate)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
  • Alternative Names
  • VTCN1; V-set domain containing T cell activation inhibitor 1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291; V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4; B7 family member, H4; B7 superfamily member 1; T cell costimulatory molecule B7x; T-cell costimulatory molecule B7x; immune costimulatory protein B7-H4;

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Chimeric Antibody

CAT Product Name Application Type
TAB-1110CL Human Anti-VTCN1 Recombinant Antibody (TAB-1110CL) ELISA, FC Chimeric (Mouse/Human) IgG4
TAB-1112CL Human Anti-VTCN1 Recombinant Antibody (TAB-1112CL) ELISA, FC Chimeric (Mouse/Human) IgG4
TAB-1114CL Human Anti-VTCN1 Recombinant Antibody (TAB-1114CL) ELISA, FC Chimeric (Mouse/Human) IgG4
TAB-1112CL-F(E) Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1112CL-F(E)) ELISA, FC Chimeric (Mouse/Human) Fab
TAB-1114CL-F(E) Human Anti-VTCN1 Recombinant Antibody; Fab Fragment (TAB-1114CL-F(E)) ELISA, FC Chimeric (Mouse/Human) Fab

Neutralizing Antibody

CAT Product Name Application Type
NEUT-2275CQ Rat Anti-Vtcn1 Recombinant Antibody (clone 188) FC, FuncS, Neut Rat IgG2b, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3857 Rabbit Anti-VTCN1 Recombinant Antibody (clone DS3857AB) WB, IHC, ICC, IP Rabbit IgG

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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