Anti-CD70 (h1F6)-β-glucuronide-potent doxorubicin ADC (CAT#: ADC-082LCT)
This ADC product is composed of an anti-CD70 antibody (clone h1F6) conjuagated via a β-glucuronide linker to Doxorubicin (h1F6-β-glucuronide-potent doxorubicin). It has demonstrated a response in lymphomas and renal cell carcinoma treatment by a MOA (Mechanism of Action) of Inhibit Topoisomerase I and cause DNA damage.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1486_B2_3_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/46582/1559_D6_2_red_green.jpg
Figure 3 RNA cell line category: Cell line enhanced (SiHa, THP-1, U-251 MG, U-266/70, U-266/84, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000125726-CD70
Specifications
- Antibody Overview
- 1F6 (Humanized Anti-CD70)
- Clone
- h1F6
- Antibody Isotype
- IgG1
- Linker
- β-glucuronide linker
- Linker Class/Description
- β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
- Drug
- Doxorubicin
- Drug Class/Description
- Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
Target
- Introduction
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- Alternative Names
- CD70; CD70 molecule; CD27L; CD27LG; TNFSF7; CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7;
- Gene ID
- 970
- UniProt ID
- P32970
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1584z | Mouse Anti-CD70 Recombinant Antibody (clone 24B8) | FC, IF, IHC, IP | Mouse IgG1, κ |
| MOB-1639MZ | Recombinant Mouse Anti-Human CD70 Antibody (clone CV70) | ELISA, FC, FuncS, IHC-Fr, IP | Mouse antibody |
| MOB-072LC | Human Anti-CD70 Recombinant Antibody (MOB-072LC) | ELISA, FC, FuncS | Human IgG |
| MOB-073LC | Mouse Anti-CD70 Recombinant Antibody (clone hCD70.21) | ELISA, FC, FuncS | Mouse IgG |
| FN-046CQ | Mouse Anti-CD70 Recombinant Antibody (clone BU69) | ELISA, FC, Block, ICC, IHC | Mouse IgG1 |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-342LC | Human Anti-CD70 Recombinant Antibody (TAB-342LC) | FC | Humanized IgG |
| TAB-335LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-335LC-F(E)) | ELISA | Humanized Fab |
| TAB-342LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-342LC-F(E)) | FC | Humanized Fab |
| TAB-343LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-343LC-F(E)) | FC | Humanized Fab |
| TAB-344LC-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (TAB-344LC-F(E)) | FC | Humanized Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-336LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (Mb VLVH) | FC, ELISA | Human antibody |
| TAB-337LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (Mb VHVL) | FC, ELISA | Human antibody |
| TAB-338LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (VL-5-VH) | FC, ELISA | Human antibody |
| TAB-339LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (VH-5-VL) | FC, ELISA | Human antibody |
| TAB-340LC-S(P) | Anti-Human CD70 Recombinant Antibody scFv Fragment (VL-8-VH) | FC, ELISA | Human antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-403CQ | Rat Anti-Cd70 Recombinant Antibody (clone 9G24) | ELISA, Neut | Rat IgG1 |
| NEUT-405CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL684) | ELISA, Neut | Rat IgG1 |
| NEUT-406CQ | Rat Anti-Cd70 Recombinant Antibody (clone FR70) | FC, FuncS, Neut, IP | Rat IgG2b, κ |
| NEUT-407CQ | Rat Anti-Cd70 Recombinant Antibody (clone CBL856) | ELISA, Neut | Rat IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-404CQ | Rat Anti-Cd70 Recombinant Antibody (clone MAB0825) | Block, FC, Inhib, IP | Rat IgG2 |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H76 | Afuco™ Anti-CD70 ADCC Recombinant Antibody (Vorsetuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0468-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0468-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0469-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0469-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0470-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0470-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0471-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0471-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0472-WJ-F(E) | Human Anti-CD70 Recombinant Antibody; Fab Fragment (HPAB-0472-WJ-F(E)) | ELISA | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0471-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0471-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0472-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0472-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0473-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0473-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0474-WJ-S(P) | Human Anti-CD70 Recombinant Antibody; scFv Fragment (HPAB-0474-WJ-S(P)) | ELISA | Human scFv |
| HPAB-AP584-YC-S(P) | Mouse Anti-CD70 Recombinant Antibody (clone m1F6); scFv Fragment | FC, ADCC, CDC, FuncS | Mouse scFv |
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