Anti-MSLN (clone h7D9.v3)-mc-vc-PABC-MMAF ADC (CAT#: ADC-227LZY)

This ADC product is composed of an anti-MSLN antibody (clone h7D9v3 ) conjugated via mc-vc-PABC linker to MMAF (h7D9v3-mc-vc-PABC-MMAF). It has demonstrated a response in epithelial cancers treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized Anti-MSLN mAb,h7D9.v3
  • Clone
  • h7D9v3
  • Linker
  • mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAF (monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
  • Alternative Names
  • MSLN; mesothelin; MPF; SMRP; CAK1 antigen; megakaryocyte potentiating factor; soluble MPF mesothelin related protein; pre-pro-megakaryocyte-potentiating factor;

Downloads

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Single-domain Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-201 Anti-Human Mesothelin Recombinant Antibody (Amatuximab) IP, IF, FuncS, FC, Neut, ELISA, IHC IgG1 - kappa

Immunotoxin

CAT Product Name Application Type
AGTO-G052E Anti-MSLN immunotoxin RG7787 (Fab)-PE Cytotoxicity assay, Function study
AGTO-G053E Anti-Msln immunotoxin (IgG)-PE Cytotoxicity assay, Function study
AGTO-L035E anti-MSLN immunotoxin K1 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L063E anti-MSLN immunotoxin 8B35 (scFv)-PE Cytotoxicity assay, Functional assay

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0376MZ Chicken Anti-MSLN Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-201 Afuco™ Anti-MSLN ADCC Recombinant Antibody (Amatuximab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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