Anti-CD19 (hBU12)-Mc-MMAE ADC (CAT#: ADC-019LCT)

This ADC product is composed of an anti-CD19 antibody (clone hBU12) conjuagated via a Mc linker to MMAE (hBU12-Mc-MMAE). It has demonstrated a response in AML, NHL treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Fully Human Anti-CD19 mAb
  • Clone
  • hBU12
  • Linker
  • Mc (maleimidocaproyl)
  • Linker Class/Description
  • Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • MMAE (Monomethyl auristatin E)
  • Drug Class/Description
  • Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • CD19; CD19 molecule; B4; CVID3; B-lymphocyte antigen CD19; differentiation antigen CD19; T-cell surface antigen Leu-12; B-lymphocyte surface antigen B4;

Related Resources

  • Related Diseases

Downloads

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Humanized Antibody

CAT Product Name Application Type
TAB-H17 Anti-Human CD19 Recombinant Antibody (Denintuzumab Mafodotin) IF, IP, Neut, FuncS, ELISA, FC, WB IgG1 - kappa
TAB-1612CL Human Anti-CD19 Recombinant Antibody (TAB-1612CL) Depletion, FuncS Humanized IgG1
TAB-1612CL-S(P) Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1612CL-S(P)) Depletion, FuncS Humanized scFv
TAB-1625CL-S(P) Anti-Human CD19 Recombinant Antibody scFv Fragment (396) Depletion, ELISA Humanized antibody
TAB-431CQ Anti-Human CD19 Recombinant Antibody ELISA, IHC, FC, IP, IF, FuncS IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-L047E anti-CD19 immunotoxin HD37 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L047D anti-CD19 immunotoxin HD37 (scFv)-DT Cytotoxicity assay, Functional assay
AGTO-L047R anti-CD19 immunotoxin HD37 (scFv)-RTA Cytotoxicity assay, Functional assay
AGTO-L047S anti-CD19 immunotoxin HD37 (scFv)-Sap Cytotoxicity assay, Functional assay
AGTO-L047P anti-CD19 immunotoxin HD37 (scFv)-PAP Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-1613CL Human Anti-CD19 Recombinant Antibody (TAB-1613CL) Cyt, FC, FuncS, Inhib Chimeric (mouse/human) IgG1
TAB-1621CL Anti-Human CD19 Recombinant Antibody (cHD37) ADCC, FuncS Chimeric antibody (mouse/human)
TAB-1613CL-F(E) Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) Depletion, FuncS Chimeric (mouse/human) Fab
TAB-1614CL-F(E) Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1614CL-F(E)) FuncS Chimeric (mouse/human) Fab
TAB-1621CL-F(E) Anti-Human CD19 Recombinant Antibody Fab Fragment (cHD37) FuncS Chimeric antibody (mouse/human)

Low- or Non-fucosylated Oligosaccharide

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0100MZ Chicken Anti-CD19 Polyclonal IgY WB Chicken antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-286CQ Mouse Anti-CD19 Recombinant Antibody (clone SJ25-C1) Neut, FC, IHC, IHC-Fr, IP Mouse IgG1
NEUT-287CQ Mouse Anti-CD19 Recombinant Antibody (clone HIB19) FC, CyTOF, IHC, Block Mouse IgG1, κ

Blocking Antibody

CAT Product Name Application Type
NEUT-288CQ Rat Anti-CD19 Recombinant Antibody (clone 1D3) Depletion, Block, FC Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0538 Hi-Affi™ Rabbit Anti-CD19 Recombinant Antibody (clone DS538AB) IHC-P Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-174 Afuco™ Anti-CD19 ADCC Recombinant Antibody (Taplitumomab), ADCC Enhanced ELISA, IP, FC, FuncS, Neut, IF ADCC enhanced antibody

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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