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Anti-Trop-2-CL2E-SN-38 ADC (CAT#: ADC-148LZY)

This ADC product is composed of an anti-Trop-2 antibody conjugated via CL2E
linker to SN-38 (CL2E-SN-38). It has demonstrated a response in Epithelial cancers treatment by a MOA (Mechanism of Action) of inhibiting Topoisomerase I and causing DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
Normal Tissue
Figure 3 Urinary bladder
Figure 3 Urinary bladder
(Urothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2

Specifications

  • Antibody Overview
  • Humanized Anti-Trop-2 mAb
  • Linker
  • CL2E
  • Linker Class/Description
  • Class: Enzymatically cleavable linker-Peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • SN-38(7-ethyl-10-hydroxy camptothecin)
  • Drug Class/Description
  • Class: SN-38
    Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1

Target

  • Introduction
  • This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
  • Alternative Names
  • TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;

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Mouse Antibody

CAT Product Name Application Type
TAB-0448CL Mouse Anti-TACSTD2 Recombinant Antibody (TAB-0448CL) FuncS Mouse IgG
TAB-0449CL Mouse Anti-TACSTD2 Recombinant Antibody (TAB-0449CL) FuncS Mouse IgG
TAB-0450CL Mouse Anti-TACSTD2 Recombinant Antibody (TAB-0450CL) WB, FC, IHC, Cyt Mouse IgG
TAB-0451CL Mouse Anti-TACSTD2 Recombinant Antibody (TAB-0451CL) FuncS Mouse IgG
TAB-0452CL Mouse Anti-TACSTD2 Recombinant Antibody (TAB-0452CL) FuncS Mouse IgG

Humanized Antibody

CAT Product Name Application Type
TAB-504CT Humanized Anti-TACSTD2 Recombinant Antibody (TAB-504CT) FC, WB, ELISA Humanized IgG
TAB-504CT-S(P) Humanized Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-504CT-S(P)) FC, WB, ELISA Humanized scFv
TAB-504CT-F(E) Humanized Anti-TACSTD2 Recombinant Antibody; Fab Fragment (TAB-504CT-F(E)) FC, WB, ELISA Humanized Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4446 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI539DS) FC IgG
MOR-4447 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI540DS) WB, ELISA, IHC-P IgG
MOR-4448 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI541DS) ICC/IF, FC, IF IgG
MOR-4449 Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI542DS) ELISA IgG

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0303CQ-F(E) Mouse Anti-TACSTD2 Recombinant Antibody (clone AR47A6.4.2 (AR002)); Fab Fragment FC, IP, WB, IHC, FuncS, Cyt Mouse Fab
HPAB-0304CQ-F(E) Human Anti-TACSTD2 Recombinant Antibody (clone huAR47A6.4.2); Fab Fragment FC, IP, WB, IHC, FuncS, Cyt Human Fab
HPAB-627-FY-F(E) Human Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-627-FY-F(E)) WB, FC, ELISA Humanized Fab
HPAB-628-FY-F(E) Human Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-628-FY-F(E)) WB, FC, ELISA Humanized Fab
HPAB-0653-WJ-F(E) Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0653-WJ-F(E)) ELISA Mouse Fab

Recombinant Antibody

CAT Product Name Application Type
HPAB-0653-WJ Mouse Anti-TACSTD2 Recombinant Antibody (HPAB-0653-WJ) ELISA Mouse IgG
HPAB-0654-WJ Human Anti-TACSTD2 Recombinant Antibody (HPAB-0654-WJ) ELISA Humanized IgG
HPAB-0655-WJ Mouse Anti-TACSTD2 Recombinant Antibody (HPAB-0655-WJ) ELISA Mouse IgG
HPAB-0656-WJ Human Anti-TACSTD2 Recombinant Antibody (HPAB-0656-WJ) ELISA Humanized IgG
VS-0723-WK54 Human Anti-TACSTD2 Recombinant Antibody (clone Sacituzumab) ELISA, FC Human IgG1

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0653-WJ-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0653-WJ-S(P)) ELISA Mouse scFv
HPAB-0654-WJ-S(P) Human Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0654-WJ-S(P)) ELISA Humanized scFv
HPAB-0655-WJ-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0655-WJ-S(P)) ELISA Mouse scFv
HPAB-0656-WJ-S(P) Human Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0656-WJ-S(P)) ELISA Humanized scFv
HPAB-0736-WJ-S(P) Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0736-WJ-S(P)) ELISA Mouse scFv

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