Anti-EGP-1-SN-38 ADC (CAT#: ADC-122CL)
This ADC product is composed of an anti-EGP-1 antibody conjugated via linker to SN-38(SN-38). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of Inhibiting Topoisomerase I and causing DNA damage.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/if_selected.jpg
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/55067/893_A3_7_blue_red_green.jpg
Figure 3 Urinary bladder
(Urothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
(Urothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43104/93730_A_6_5.jpg
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
Figure 4 RNA cell line category: Cell line enhanced (A-431, CAPAN-2, HaCaT, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184292-TACSTD2
Specifications
- Antibody Overview
- Humanized Antibody, (Anti-EGP-1)
- Drug
- SN-38 (7-ethyl-10-hydroxycamptothecin)
- Drug Class/Description
- Class: SN38
Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.
Target
- Introduction
- This intronless gene encodes a carcinoma-associated antigen. This antigen is a cell surface receptor that transduces calcium signals. Mutations of this gene have been associated with gelatinous drop-like corneal dystrophy.[provided by RefSeq, Dec 2009]
- Alternative Names
- TACSTD2; tumor-associated calcium signal transducer 2; EGP1; GP50; M1S1; EGP-1; TROP2; GA7331; GA733-1; epithelial glycoprotein-1; cell surface glycoprotein TROP2; cell surface glycoprotein Trop-2; pancreatic carcinoma marker protein GA7331; pancreatic carcinoma marker protein GA733-1; gastrointestinal tumor-associated antigen GA7331; membrane component chromosome 1 surface marker 1; membrane component, chromosome 1, surface marker 1; 40kD glycoprotein, identified by monoclonal antibody GA733;
- Gene ID
- 4070
- UniProt ID
- P09758
Downloads
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See other products for "TACSTD2"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1222z | Mouse Anti-TACSTD2 Recombinant Antibody (clone 22B1) | WB, IP, IF, IHC, ELISA | Mouse IgG1, κ |
| MOB-1932CT | Recombinant Mouse anti-Human TACSTD2 Monoclonal antibody (273-57.3) | ICC/IF, IHC-P | |
| HPAB-0303CQ | Mouse Anti-TACSTD2 Recombinant Antibody (clone AR47A6.4.2 (AR002)) | ELISA, Inhib | Mouse IgG2a, κ |
| HPAB-627-FY | Human Anti-TACSTD2 Recombinant Antibody (HPAB-627-FY) | ELISA, PP, FC | Humanized IgG1, κ |
| HPAB-628-FY | Human Anti-TACSTD2 Recombinant Antibody (HPAB-628-FY) | PP, ELISA, FC, ADCC, Inhib | Humanized IgG1, κ |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0448CL-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0448CL-S(P)) | FuncS | Mouse scFv |
| TAB-0449CL-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0449CL-S(P)) | FuncS | Mouse scFv |
| TAB-0450CL-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0450CL-S(P)) | WB, FC, IHC, FuncS | Mouse scFv |
| TAB-0451CL-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0451CL-S(P)) | FuncS | Mouse scFv |
| TAB-0452CL-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-0452CL-S(P)) | FuncS | Mouse scFv |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-504CT | Humanized Anti-TACSTD2 Recombinant Antibody (TAB-504CT) | FC, WB, ELISA | Humanized IgG |
| TAB-504CT-S(P) | Humanized Anti-TACSTD2 Recombinant Antibody; scFv Fragment (TAB-504CT-S(P)) | FC, WB, ELISA | Humanized scFv |
| TAB-504CT-F(E) | Humanized Anti-TACSTD2 Recombinant Antibody; Fab Fragment (TAB-504CT-F(E)) | FC, WB, ELISA | Humanized Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4446 | Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI539DS) | FC | IgG |
| MOR-4447 | Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI540DS) | WB, ELISA, IHC-P | IgG |
| MOR-4448 | Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI541DS) | ICC/IF, FC, IF | IgG |
| MOR-4449 | Hi-Affi™ Recombinant Rabbit Anti-TACSTD2 Monoclonal Antibody (SI542DS) | ELISA | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0303CQ-F(E) | Mouse Anti-TACSTD2 Recombinant Antibody (clone AR47A6.4.2 (AR002)); Fab Fragment | FC, IP, WB, IHC, FuncS, Cyt | Mouse Fab |
| HPAB-0304CQ-F(E) | Human Anti-TACSTD2 Recombinant Antibody (clone huAR47A6.4.2); Fab Fragment | FC, IP, WB, IHC, FuncS, Cyt | Human Fab |
| HPAB-0653-WJ-F(E) | Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0653-WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-0654-WJ-F(E) | Human Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0654-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-0655-WJ-F(E) | Mouse Anti-TACSTD2 Recombinant Antibody; Fab Fragment (HPAB-0655-WJ-F(E)) | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0303CQ-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody (clone AR47A6.4.2 (AR002)); scFv Fragment | FC, IP, WB, IHC, FuncS, Cyt | Mouse scFv |
| HPAB-0304CQ-S(P) | Human Anti-TACSTD2 Recombinant Antibody (clone huAR47A6.4.2); scFv Fragment | FC, IP, WB, IHC, FuncS, Cyt | Human scFv |
| HPAB-0653-WJ-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0653-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-0654-WJ-S(P) | Human Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0654-WJ-S(P)) | ELISA | Humanized scFv |
| HPAB-0655-WJ-S(P) | Mouse Anti-TACSTD2 Recombinant Antibody; scFv Fragment (HPAB-0655-WJ-S(P)) | ELISA | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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