Anti-DLL3 (clone SC16.56)-PBD dimers ADC (CAT#: ADC-138CL)

This ADC product is composed of an anti-DLL3 antibody (clone SC16.56) conjugated via linker to PBD dimers(hSC16.56-ADC1). It has demonstrated a response in NETs treatment by a MOA (Mechanism of Action) of binding to DNA minor groove and causing DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
RNA Expression

Specifications

  • Antibody Overview
  • Anti-DLL3 Antibody Humanized SC16.56
  • Clone
  • SC16.56
  • Drug
  • pyrrolobenzodiazepine (PBD) dimers
  • Drug Class/Description
  • Class: Pyrrolobenzodiazepine (PBD) dimmers
    Description: Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

Target

  • Introduction
  • This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3;

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Mouse Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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