Anti-DR5 (hTRA-8)-mc-MMAF ADC (CAT#: ADC-096LCT)
This ADC product is composed of an anti-DR5 antibody (clone hTRA-8) conjuagated via a Mc linker to MMAF (hTRA-8-mc-MMAF). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
(Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Neuropil
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg
Figure 2 Colon
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
(Endothelial cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg
Figure 3 Liver
(Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
(Cholangiocytes
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg
Figure 4 Kidney
(Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
(Cells in glomeruli
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg
Figure 5 Testis
(Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
(Cells in seminiferous ducts
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg
Figure 6 Lymph node
(Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
(Non-germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
(Cell lines ordered by descending RNA expression order.)
* https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B
Specifications
- Antibody Overview
- Humanized monoclonal Antibody (Anti-hTRA-8)
- Clone
- hTRA-8
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
- Alternative Names
- TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5; tumor necrosis factor receptor superfamily member 10B; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; TNF receptor superfamily member 10b; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer);
- Gene ID
- 8795
- UniProt ID
- O14763
Downloads
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Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-052 | Recombinant Anti-human TNFRSF10B VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| HPAB-0703-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (3-DR5) | ELISA, Apop | Camelid VHH |
| HPAB-0704-YJ-VHH | Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (6-DR5) | ELISA | Camelid VHH |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195 | Anti-Human TRAIL-R2 Recombinant Antibody (Lexatumumab) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - lambda |
| TAB-180 | Anti-Human DR5 Recombinant Antibody (Drozitumab) | FuncS, IF, Neut, ELISA, FC, IP, ICC | IgG1 - lambda |
| TAB-253MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU11) | FC, ELISA | Human antibody |
| TAB-254MZ-S(P) | Anti-Human TNFRSF10B Recombinant Antibody scFv Fragment (AU12) | FC, ELISA | Human antibody |
| TAB-253MZ-F(E) | Anti-Human TNFRSF10B Recombinant Antibody Fab Fragment (AU11) | FC, ELISA | Human antibody |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-625CL | Human Anti-TNFRSF10B Recombinant Antibody (TAB-625CL) | ELISA | Single Domain Antibody |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBW-057 | Human Anti-TNFRSF10B Recombinant Antibody (clone YSd1); Fab Fragment | ELISA | Human Fab |
| PFBC-123 | Human Anti-TNFRSF10B Recombinant Antibody (clone BDF1); Fab Fragment | ELISA | Human Fab |
| HPAB-0412-CN-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0412-CN-F(E)) | WB, ELISA | Human Fab |
| HPAB-0941-FY-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0941-FY-S(P)) | ELISA | Human scFv |
| HPAB-1180WJ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody (clone TRA-8); Fab Fragment | ELISA, WB | Humanized Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-247MZ | Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-247MZ) | ELISA, FC, FuncS, Inhib | Mouse IgG3, κ |
| TAB-248MZ | Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-248MZ) | ELISA, FuncS, Inhib | Mouse IgG |
| TAB-249MZ | Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-249MZ) | ELISA, FuncS, Inhib | Mouse IgG |
| TAB-252MZ | Anti-Human TNFRSF10B Recombinant Antibody | ELISA | |
| TAB-247MZ-F(E) | Mouse Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-247MZ-F(E)) | ELISA, WB | Mouse Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-250MZ | Human Anti-TNFRSF10B Recombinant Antibody (TAB-250MZ) | FuncS | Humanized IgG |
| TAB-251MZ | Human Anti-TNFRSF10B Recombinant Antibody (TAB-251MZ) | FuncS | Humanized IgG |
| TAB-250MZ-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-250MZ-S(P)) | FC, ELISA | Humanized scFv |
| TAB-250MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-250MZ-F(E)) | FC, ELISA | Humanized Fab |
| TAB-251MZ-F(E) | Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (TAB-251MZ-F(E)) | FC, ELISA | Humanized Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3604 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone DS3604AB), PE | FC, WB | Rabbit IgG |
| MOR-3605 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone DS3605AB) | ELISA | Rabbit IgG |
| MOR-4468 | Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone SI562DS) | ELISA | Rabbit IgG |
| MOR-4469 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI563DS) | ELISA, FC | Rabbit IgG |
| MOR-4473 | Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI567DS) | FC | Rabbit IgG |
Agonistic Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-104LC | Human Anti-TNFRSF10B Recombinant Antibody (MOB-104LC) | FuncS | Chimeric (mouse/human) IgG1, κ |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0412-CN | Human Anti-TNFRSF10B Recombinant Antibody (HPAB-0412-CN) | WB, ELISA | Human IgG1, λ |
| FN-054CQ | Mouse Anti-TNFRSF10B Recombinant Antibody (clone HS201) | FC, Inhib, ICC, IP | Mouse IgG1 |
| FN-235CQ | Hamster Anti-Tnfrsf10b Recombinant Antibody (clone MD5-1) | FC, FuncS | Hamster IgG |
| HPAB-1145WJ | Mouse Anti-TNFRSF10B Recombinant Antibody (clone E-11-13) | ELISA, FC | Mouse IgG1 |
| HPAB-1146WJ | Mouse Anti-TNFRSF10B Recombinant Antibody (clone L-30-10) | ELISA, FC | Mouse IgG1 |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-196 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody (Tigatuzumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-203 | Afuco™ Anti-TNFRSF10B Recombinant Antibody (AFC-TAB-203), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | Human IgG1, κ |
| AFC-TAB-180 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody (Drozitumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-195 | Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody (Lexatumumab), ADCC Enhanced | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0268-YC-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-N0268-YC-S(P)) | FC, Inhib | Human scFv |
| HPAB-2047-FY-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-2047-FY-S(P)) | IA | Human scFv |
| HPAB-0672YY-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0672YY-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0673YY-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0673YY-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0674YY-S(P) | Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0674YY-S(P)) | ELISA, FuncS | Human scFv |
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