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IgG(L,H)-Fv Bispecific Antibody (BsAb)

Creative Biolabs scientists have strong technical knowledge in IgG(L,H)-Fv bispecific antibody (BsAb) design and construction. We work closely with our customers so as to meet their individual requirements with the best service.



Figure: Diagram of IgG(L,H)-Fv BsAb (Mol Immunol, 2015)

IgG(L,H)-Fv BsAbs, one kind of bispecific antibodies with the improved feature and promising therapeutic potential, are constructed by appending VH and VL domains to the C-terminal of two distinct heavy chains. It is essentially a full-length antibody with an additional C-terminal Fv region. The engineered C-terminal Fv is monovalent while the two identical N-terminal Fv regions are those of a typical full-length IgG which provide bivalent antigen binding activity. The C-terminal VH/VL pairing may further contribute to the hetero-specificity of the heavy chains, which enables the IgG(L,H)-Fv to co-engage distinctly target antigens with different valencies simultaneously.

Creative Biolabs focuses on providing good products, excellent credit and enthusiastic services for our customers. With our rich experience in antibody engineering, we are confident to deliver you a IgG(L,H)-Fv bispecific antibody that meets all your required specifications.

Christoph Spiess, et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol. 2015 Oct; 67(2 Pt A):95-106.

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