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IgG-scFv Bispecific Antibody (BsAb)

Creative Biolabs provides a first-class construction service for many different types of IgG-scFv bispecific antibodies (BsAbs). Our strong expertise in constructing bispecific antibodies allows us to generate complex IgG-scFv BsAbs. The antibody types that we can offer include IgG(H)-scFv or scFv-(H)IgG; IgG(L)-scFv or scFv-(L)IgG; and 2scFv-IgG or IgG-2scFv.


Figure: Alternative formats for IgG-scFv BsAbs (Mol Immunol, 2015)

IgG-scFv BsAb is a kind of bispecific antibodies which is engineered for bispecificity by fusing two scFvs respectively to a monospecific IgG. The specificity of each scFv can be same or different. Furthermore, either the amino or the carboxy terminus of each light or heavy chain can be appended with paired antibody variable domains, which leads to the production of diverse types of IgG-scFv BsAbs:

  1. IgG(H)-scFv or scFv-(H)IgG: IgG(H)-scFv, two scFvs with same specificity linked to the C terminus of the full-length IgG HC; scFv-(H)IgG, which is same like IgG(H)-scFv, except that the scFvs are linked to the HC N terminus.
  2. IgG(L)-scFv or scFv-(L)IgG: the two same scFvs connected to the C or N terminus of the IgG light chain, which forms the IgG(L)-scFv or scFv-(L)IgG, respectively.
  3. 2scFv-IgG or IgG-2scFv: generated by fusing two paired scFvs with different specificity to either the N terminus (2scFv-IgG) or the C terminus (IgG-2scFv).

Creative Biolabs has system construction experience in the field of antibody engineering. With our most excellent scientists, we are confident to deliver you a bispecific antibody that can meet all your required specifications.

Christoph Spiess, et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol. 2015 Oct; 67(2 Pt A):95-106.

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