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IgG-v Bispecific Antibody (BsAb)

Creative Biolabs provides professional IgG-v bispecific antibody (BsAb) design and construction services for diverse studies about therapeutic antibody engineering. We can offer clients four different formats of IgG-v BsAbs including: IgG(H)-V, V(H)-IgG, IgG(L)-V, and V(L)-IgG to meet different customer’s special requirements.



Figure: Alternative formats for IgG-v BsAbs (Mol Immunol, 2015)

IgG-v bispecific antibodies are engineered by appending paired antibody variable domains Fv to the N or C terminus of the heavy or the light chain of an antibody, resulting in multi specific molecules with two binding sites for each antigen. They are the major class of appending IgG-like molecules which provide great starting points to design the most appropriate therapeutic antibodies so as to achieve the expected mechanisms and application potential. Depending on the strategy used for appending Fv to the whole IgG, there are four different formats of IgG-v BsAbs:

  1. IgG(H)-V: a Fv domain linked to each of the C terminus of IgG HC;
  2. V(H)-IgG: a Fv domain linked to each of the N terminus of the IgG HC;
  3. IgG(L)-V: a Fv domain linked to each of the C terminus of the IgG LC;
  4. V(L)-IgG: a Fv domain linked to each of the N terminus of the IgG LC.

Creative Biolabs has been focused on bispecific antibody design and construction for many years in the field of antibody engineering. We have established world-leading platforms for antibody engineering and production. You will never regret to choose us for your specific antibody generation.

Christoph Spiess, et al. Alternative molecular formats and therapeutic applications for bispecific antibodies. Mol Immunol. 2015 Oct; 67(2 Pt A):95-106.

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