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Immunology

Creative Biolabs is dedicated to bispecific antibody (BsAb) applications in different clinical domains such as immunology. We can provide custom BsAbs against immune-associated inflammatory diseases.

Psoriasis, rheumatoid arthritis (RA) and osteoarthritis (OA) are common autoimmune disorders. The causes of these diseases are still unclear, although the immune system attacking self antigens is the basic mechanism. However, therapeutic agents interfering pro-inflammatory pathway have been proved to be effective. There have been several BsAbs in clinical trials for treating different inflammatory diseases: ABT-981 (Phase II, OA), ABT-122 (Phase II, RA), COVA322 (Phase I/II, Plaque psoriasis), ALX-0061 (Phase I/II, RA) and Ozoralizumab (Phase II, RA). Innovative scientists from Creative Biolabs select the major cytokines such as interleukins and TNF, which play important roles in immune regulation and inflammatory processes, as targets to design bispecific antibodies e.g. DVD-Ig, single domain antibody, etc. Administration of these BsAbs can block relevant pro-inflammatory cytokines to perform anti-disease activities. Additionally, BsAbs can be linked to human serum albumin (HSA) to increase their half-life in serum.

Creative Biolabs has developed diverse BsAb formats which can assist our clients to accelerate the development of BsAbs.

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