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KIH IgG-scFab BsAb

Creative Biolabs offers clients design and construction services of a novel form bispecific antibodies, the KIH IgG-scFab, for many different studies about antibody engineering. We are confident to deliver you a bispecific antibody that can meet all of your required specifications.



Figure: Schematic representation of the KIH IgG-scFab antibody (Molecular Immunology, 2015)

KIH IgG-scFab, a new form of appending IgG-like bispecific antibodies, is engineered by fusing a scFab domain to the C-termini of IgG heavy chain modified by knobs-into-holes (KIH) technique. Hence, when co-expressed in one cell, Knob-modified Fv tend to pair with Hole-modified Fv, which effectively results in the production of asymmetric antibodies with dual specificities. Up to now, variant approaches have been established based on KIH method, such as using alternative mutations, electrostatic steering effects, or hybrid CH3 domains derived from IgG and IgA. KIH IgG-scFab can effectively prevent the formation of homodimer which inevitably happens during conventional bispecific IgG synthesis. Furthermore, this strategy makes it feasible to produce BsAb in industrial scale.

Professional teams from Creative Biolabs dedicate our talent and expertise to providing not only the first-class services, but also the most competitive price for our customers.

Christoph Spiess, Qianting Zhai, Paul J. Carter. Alternative molecular formats and therapeutic applications for bispecific antibodies. Molecular Immunology 2015, 67, 95–106.

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