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Mini-antibody

Creative Biolabs possesses unchallenged experience in diverse bispecific antibody (BsAb) synthesis, such as mini-antibody. Our platforms cover fields from recombinant protein synthesis to epitope mapping, all of which are elaborately integrated for providing an expected mini-antibody with desired specificity and affinity.


Figure: Diagram of the structure of mini-antibodies

Mini-antibody is a group of artificial immunoglobins without CH1 domain. Each single chain of a mini-antibody is expressed separately in prokaryotic or eukaryotic expression system and linked to another signle chain with distinct specificity via chemical modification or knobs-and-holes approach to get bispecific antibody. Removal of CH1 domain does not reduce the affinity of antibody to its targets. On the contrary, the decreased size makes mini-antibodies perform better in tissue penetration than conventional IgG-BsAbs, which is an ideal character for disease treatment and immune research.

Creative Biolabs takes all concerns of customer, such as budget and time, into serious consideration during planning the bispecific mini-antibody production. We are confident of promising our mini-antibodies with experimentally confirmed high-affinity to almost any pair of antigens of interest.

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