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Anti-CD138 (nBT062)-SPP-DM1 ADC (CAT#: ADC-016LCT)

This ADC product is composed of an anti-CD138 antibody (clone nBT062) conjuagated via a SPP linker to DM1 (nBT062-SPP-DM1). It has demonstrated a response in multiple myeloma treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to focal adhesion sites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_B_8_5.jpg
Figure 3 Colon
Figure 3 Colon
(Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_3.jpg
Figure 4 Testis
Figure 4 Testis
(Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_4_6.jpg
Figure 5 Placenta
Figure 5 Placenta
(Syncytiotrophoblasts - cell body Staining: High Intensity: Strong Quantity:>75% Syncytiotrophoblasts - microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_1_7.jpg
Figure 6 Lymph node
Figure 6 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6185/40538_A_7_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
Figure 7 RNA cell line category: Cell line enhanced (HBEC3-KT, hTCEpi, U-251 MG, U-266/70, U-266/84)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115884-SDC1

Specifications

  • Antibody Overview
  • Murine/Human Chimeric CD138-specific monoclonal Antibody nBT062
  • Clone
  • nBT062
  • Antibody Isotype
  • IgG4
  • Linker
  • SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Linker Class/Description
  • Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
  • Drug Class/Description
  • Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells

Target

  • Introduction
  • The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • SDC1; syndecan 1; SDC; CD138; SYND1; syndecan; syndecan-1; CD138 antigen; syndecan proteoglycan 1; heparan sulfate proteoglycan fibroblast growth factor receptor;

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Chimeric Antibody

CAT Product Name Application Type
TAB-197 Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (clone Indatuximab) Neut, ELISA, IF, IP, FuncS, FC, ICC Chimeric (mouse/Human) IgG4, κ

Mouse Antibody

CAT Product Name Application Type
TAB-495CT Mouse Anti-SDC1 Recombinant Antibody (TAB-495CT) FC, WB Mouse IgG1, κ
TAB-495CT-S(P) Mouse Anti-SDC1 Recombinant Antibody; scFv Fragment (TAB-495CT-S(P)) FC, WB Mouse scFv
TAB-495CT-F(E) Mouse Anti-SDC1 Recombinant Antibody; Fab Fragment (TAB-495CT-F(E)) FC, WB Mouse Fab

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3189 Hi-Affi™ Recombinant Rabbit Anti-SDC1 Monoclonal Antibody (DS3189AB) IHC-P IgG

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0324-CN-S(P) Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-0324-CN-S(P)) ELISA, FC Human scFv
HPAB-0326-CN-S(P) Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-0326-CN-S(P)) ELISA, FC Human scFv
HPAB-2546LY-S(P) Human Anti-SDC1 Recombinant Antibody; scFv Fragment (HPAB-2546LY-S(P)) ELISA Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0324-CN-F(E) Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0324-CN-F(E)) ELISA, FC Humanized Fab
HPAB-0326-CN-F(E) Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-0326-CN-F(E)) ELISA, FC Humanized Fab
HPAB-2546LY-F(E) Human Anti-SDC1 Recombinant Antibody; Fab Fragment (HPAB-2546LY-F(E)) ELISA Humanized Fab

Neuroscience Antibody

CAT Product Name Application Type
NS-086CN Human Anti-SDC1 Recombinant Antibody (NS-086CN) ELISA Humanized IgG
NS-087CN Human Anti-SDC1 Recombinant Antibody (NS-087CN) ELISA Humanized IgG
NS-086CN-F(E) Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-086CN-F(E)) ELISA Humanized Fab
NS-087CN-F(E) Human Anti-SDC1 Recombinant Antibody; Fab Fragment (NS-087CN-F(E)) ELISA Humanized Fab
NS-086CN-S(P) Human Anti-SDC1 Recombinant Antibody; scFv Fragment (NS-086CN-S(P)) ELISA Human scFv

Recombinant Antibody

CAT Product Name Application Type
NS-089CN Mouse Anti-SDC1 Recombinant Antibody (NS-089CN) ELISA Mouse IgG
FN-069CQ Recombinant Mouse Anti-SDC1 Antibody (B-A38) FC, IHC Mouse IgG1
HPAB-2546LY Human Anti-SDC1 Recombinant Antibody (HPAB-2546LY) ELISA Humanized IgG4
VS3-QX1001 Mouse Anti-SDC1 Recombinant Antibody (clone 587CT7.3.6.5) WB, ICC, FC Mouse IgM
VS3-CJ734 Mouse Anti-SDC1 Recombinant Antibody (VS3-CJ734) WB Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-197 Afuco™ Anti-SDC1 ADCC Recombinant Antibody (Indatuximab), ADCC Enhanced Neut, ELISA, IF, IP, FuncS, FC ADCC enhanced antibody

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