α4β7 integrin

Integrins are transmembrane receptors that are the bridges for cell-cell and cell-extracellular matrix interactions. When triggered, integrins in turn trigger chemical pathways to the interior, such as the chemical composition and mechanical status of the ECM, which results in a response such as regulation of the cell cycle, cell shape, and/or motility; or new receptors being added to the cell membrane. This allows rapid and flexible responses to events at the cell surface, for example to signal platelets to initiate an interaction with coagulation factors.