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2,3,4,7,8-PeCDF

2,3,4,7,8-pentachlorodibenzofuran is a more potent cytochrome P4501A inducer than 2,3,7,8-tetrachlorodibenzo-p-dioxin in herring gull hepatocyte cultures.

Polychlorinated dibenzofurans (PCDFs) are not manufactured commercially other than for scientifi research purposes. Release of PCDF

into the environment is mainly from combustion and incineration. Based on congenerspecifi profies, combustion sources all produce 2,3,7,8-substituted polychlorinated dibenzopara-dioxins (PCDDs) and PCDFs, including 2,3,4,7,8-pentachlorodibenzofuran (PeCDF). Th

latter substance is the major congener emitted from cement kilns burning hazardous waste (approximately 20% of the total congener emission). Other major sources of PeCDF are metal smelting, refiing, and processing; chemical manufacturing/processing (production of chlorophenols, PCBs, vinyl chloride); pulp bleaching; and existing reservoirs that reflct past releases.

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