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ABL2

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
Protein class

Cancer-related genes, Enzymes, Metabolic proteins, RAS pathway related proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells, Cone photoreceptor cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (hTERT-HME1, TIME)

Interaction

Interacts with PSMA7. Interacts with CTTN. Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases.

Molecular function

Kinase, Transferase, Tyrosine-protein kinase

More Types Infomation

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