FDA approved drug targets, G-protein coupled receptors, Human disease related genes, Transporters
Membrane
Cell type enhanced (Basal keratinocytes, Squamous epithelial cells, Suprabasal keratinocytes, Adipocytes, Basal respiratory cells)
Low immune cell specificity
Cell line enhanced (hTCEpi, hTERT-HME1, PC-3)
Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC (PubMed:9924018). Interacts with USP20 and USP33 (PubMed:19424180, PubMed:23166351). Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane. Interacts with CNIH4 (PubMed:24405750). Interacts with ARRDC3 (PubMed:20559325, PubMed:25220262). Interacts with NEDD4 (PubMed:23166351). Interacts with MARCHF2 (PubMed:23166351).
G-protein coupled receptor, Receptor, Transducer
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For Research Use Only. Not For Clinical Use.