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ANGPTL3

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
ANGPTL3
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Group enriched (Hepatocytes, Proximal tubular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Interacts with ANGPTL8. Interacts with ITGB3 (By similarity).

Molecular function

Heparin-binding

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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