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APC
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Inhibitory neurons, Bipolar cells, Oligodendrocyte precursor cells, Excitatory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms homooligomers and heterooligomers with APC2. Interacts with DIAPH1 and DIAPH2 (By similarity). Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with ARHGEF4 (via N-terminus). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with SCRIB; may mediate APC targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B (By similarity). Interacts at the cell membrane with AMER1 and AMER2 (via ARM repeats). Interacts with KHDRBS1. The complex composed, at least, of APC, CTNNB1 and GSK3B interacts with JPT1; the interaction requires the inactive form of GSK3B (phosphorylated at 'Ser-9') (PubMed:25169422).
More Types Infomation
Related Diseases
Breast Cancer
Colorectal Cancer
Endometrial Cancer
Gastric Cancer
Pancreatic Cancer
Prostate Cancer
Throid Cancer
Hepatocellular Carcinoma
Cushing Syndrome
Related Signaling Pathways
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
- Recombinant Anti-human APC Antibody scFv Fragment (MOB-72-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
- Recombinant Anti-human APC Antibody Fab Fragment (MOB-72-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, WB, FuncS
- Recombinant Anti-human APC Antibody (MOB-72)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, FC, FuncS
- Recombinant Human Anti-human APC Antibody scFv Fragment (MHH-72-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, FC, FuncS
- Recombinant Human Anti-human APC Antibody Fab Fragment (MHH-72-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: FC, Neut, Biosensors, FuncS
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: WB, FACS, FuncS
- Rabbit Anti-APC Polyclonal Antibody (MRO-1651-CN) (MRO-1651-CN)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
- Rabbit Anti-APC Recombinant Antibody (clone CBACN-035) (MRO-0106-CN)
-
- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, IP
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, ICC
- Mouse Anti-APC Recombinant Antibody (clone CBLS-110) (MOB-0647MZ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC-Fr
- Human Anti-aPC Recombinant Antibody (TAB-244CT) (TAB-244CT)
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human IgG1
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-246CT-F(E)) (TAB-246CT-F(E))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog, Mouse
- Type: Human Fab
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-245CT-F(E)) (TAB-245CT-F(E))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human Fab
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-244CT-F(E)) (TAB-244CT-F(E))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human Fab
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-243CT-F(E)) (TAB-243CT-F(E))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human Fab
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; Fab Fragment (TAB-242CT-F(E)) (TAB-242CT-F(E))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog, Mouse
- Type: Human Fab
- Application: ELISA, WB
- Mouse Anti-aPC Recombinant Antibody; Fab Fragment (TAB-241CT-F(E)) (TAB-241CT-F(E))
-
- Species Reactivity: Human
- Type: Mouse Fab
- Application: Non-neutralizing
- Human Anti-aPC Recombinant Antibody; scFv Fragment (TAB-245CT-S(P)) (TAB-245CT-S(P))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human scFv
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; scFv Fragment (TAB-244CT-S(P)) (TAB-244CT-S(P))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human scFv
- Application: ELISA, WB
- Human Anti-aPC Recombinant Antibody; scFv Fragment (TAB-243CT-S(P)) (TAB-243CT-S(P))
-
- Derivation: Fully Human Fab antibody library
- Species Reactivity: Dog
- Type: Human scFv
- Application: ELISA, WB
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