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BDKRB2

This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein.
Protein class

FDA approved drug targets, G-protein coupled receptors, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Fibroblasts, Distal enterocytes, Endothelial cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC TERT1, BJ hTERT+, U-87 MG)

Interaction

Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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