Loading...
BUB1
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Granulosa cells, Plasma cells, Erythroid cells, Spermatogonia)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (HEL)
Interaction
Interacts with BUB3 and KNL1. Interacts (when phosphorylated) with PLK1. The BUB1-BUB3 complex interacts with MAD1L1. (Microbial infection) Interacts with SV40 Large T antigen; this interaction induces activation of a DNA damage response and promotes p53/TP53 stabilization and phosphorylation. (Microbial infection) Interacts with herpes virus 8 protein LANA1.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, FC
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IF
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB
-
- Species Reactivity: Mouse, Human. Predicted to work with: Rat, Xenopus laevis, Kangaroo
- Type: Mouse IgG1
- Application: IF, WB, IP
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.