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CALCR

This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a
subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is
involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption.
Polymorphisms in this gene have been associated with variations in bone mineral density and onset of
osteoporosis. Alternate splicing results in multiple transcript variants.
Protein class

Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Skeletal myocytes, Early spermatids, Microglial cells, Late spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (RPTEC TERT1, SuSa, T-47d)

Interaction

Interacts with GPRASP2.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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