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CD18 & C3d

This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Complement is the name given to a complex series of some 20 proteins which, along with blood clotting, fibrinolysis and kinin formation, forms one of the triggered enzyme systems found in plasma. C3 is cleaved by C3 convertase into fragments including C3d.

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