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CD19 & CD22
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
CD22 (CD22 Molecule) is a Protein Coding gene. Diseases associated with CD22 include Refractory Hematologic Cancer and Refractory Hairy Cell Leukemia. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include carbohydrate binding. An important paralog of this gene is SIGLEC1.
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: IF, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, FuncS
- Recombinant Anti-Human CD22 Antibody Fab Fragment (MOB-1248z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, RIA, FuncS
- Recombinant Anti-Human CD22 Antibody scFv Fragment (MOB-1248z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IF, FuncS
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab' - G2a - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, WB
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
- anti-CD19 immunotoxin HD37 (scFv)-RTA (AGTO-L047R)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
- Anti-CD22 (clone hLL2)-SN-38 ADC (ADC-124CL)
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- Target: CD22
- Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
- Anti-CD19 immunotoxin HD37 (IgG)-DT (AGTO-G076D)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
- anti-CD19 immunotoxin HD37 (scFv)-DT (AGTO-L047D)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
- Anti-Human CD19 Recombinant Antibody (MDX-1342) (TAB-108CL)
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- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
- Application: FC, ADCC, FuncS
- anti-CD19 immunotoxin HD37 (scFv)-PE (AGTO-L047E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
- Anti-CD22 immunotoxin RFB4 (IgG)-Sap (AGTO-G077S)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
- Anti-CD19 immunotoxin HD37 (IgG)-PE (AGTO-G076E)
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- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: Humanized (from mouse) IgG4, κ
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
- Anti-Human CD22 Recombinant Antibody (Moxetumomab Pasudotox) (TAB-183-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fv - disulfide stabilized
- Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
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For Research Use Only. Not For Clinical Use.