Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Intracellular
Cell type enhanced (Late spermatids, Pancreatic endocrine cells, Early spermatids, Respiratory ciliated cells, Basal respiratory cells, Club cells)
Immune cell enhanced (T-reg)
Cell line enhanced (CAPAN-2, HEK93, HeLa, SK-MEL-30)
Heterodimer with CDK4 or CDK6. Predominant p16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2.
DNA-binding [Q8N726]
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For Research Use Only. Not For Clinical Use.