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CNTN1

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Group enriched (Oligodendrocyte precursor cells, Excitatory neurons, Astrocytes, Inhibitory neurons)

Immune cell specificity

Immune cell enhanced (basophil)

Cell line specificity

Cell line enhanced (A549, HaCaT, SCLC-21H, SH-SY5Y)

Interaction

Monomer (PubMed:2026173). Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR. Detected in a complex with NRCAM and PTPRB (By similarity). Interacts with TASOR (By similarity).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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