COL4A3

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

Intracellular, Secreted (different isoforms)

Cell type enhanced (Cone photoreceptor cells, Alveolar cells type 1, Muller glia cells, Oligodendrocyte precursor cells, Bipolar cells)

Immune cell enhanced (memory B-cell)

Cell line enhanced (HeLa, hTERT-RPE1, Karpas-707, RPTEC TERT1, U-266/70)

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite promoter, respectively (PubMed:12193605). Interacts with ITGB3 (PubMed:12682293). Associates with LAMB2 at the neuromuscular junction and in GBM (By similarity).