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CRH

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.
Protein class

Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Syncytiotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (SuSa)

Interaction

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

Molecular function

Hormone

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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