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CSF2RA

The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble.
CSF2RA
Protein class

Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Human disease related genes

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (monocytes, Langerhans cells, Syncytiotrophoblasts, Cytotrophoblasts, Extravillous trophoblasts, Macrophages)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Group enriched (BEWO, HMC-1, SK-MEL-30)

Interaction

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

Molecular function

Receptor

More Types Infomation
    • Species Reactivity: Human
    • Application: Cytotoxicity assay, Functional assay

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