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CSK
CSK (C-Terminal Src Kinase) is a Protein Coding gene. Diseases associated with CSK include Osteopetrosis and Breast Cancer. Among its related pathways are RET signaling and Oncogenic MAPK signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is MATK.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (B-cells, dendritic cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (via SH3-domain) (PubMed:19888460). Interacts with PTPN22 (PubMed:15208781). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1; these interactions serve to recruit CSK to the membrane where it can phosphorylate and inhibit Src-family kinases (PubMed:11433379, PubMed:10790433, PubMed:14610046, PubMed:10838081). Interacts with SRCIN1 (PubMed:17525734). Interacts with RHOH (PubMed:20851766). Interacts (via SH2 domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-107' (PubMed:21930792). Interacts (via SH2 domain) with PRAG1 (when phosphorylated at 'Tyr-391'); this interaction prevents translocation of CSK from the cytoplasm to the membrane leading to increased activity of CSK (By similarity).
Molecular function
Kinase, Transferase, Tyrosine-protein kinase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: IHC-P, WB
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IP
- Mouse Anti-CSK Recombinant Antibody (VS4-WK128) (VS4-WK128)
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- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse IgG2b
- Application: ELISA, WB, ICC
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Mouse IgG1
- Application: WB, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Monkey, Rat
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
-
- Derivation: Mouse
- Species Reactivity: Human, Rat
- Type: Mouse IgG2b
- Application: WB, ICC
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- Species Reactivity: Human, Rat
- Type: Mouse IgG
- Application: WB, ICC
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For Research Use Only. Not For Clinical Use.