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CSPG4

A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells.
Predicted location

Membrane

Single cell type specificity

Group enriched (Sertoli cells, Oligodendrocyte precursor cells, Smooth muscle cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (BJ, SK-MEL-30, U-138 MG, WM-115)

Interaction

Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16. (Microbial infection) Interacts with C.difficile toxin TcdB, suggesting that it may act as a receptor for TcdB.

Molecular function

Developmental protein, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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