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CXADR
The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.
Protein class
Transporters
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Proximal enterocytes)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (CACO-2, Hep G2, NTERA-2, RT4)
Interaction
Monomer. May form homodimer. Interacts with LNX, MAGI1, DLG4, PRKCABP, TJP1 and CTNNB1. Interacts with MPDZ; recruits MPDZ to intercellular contact sites. Interacts with JAML (homodimeric form). Secreted isoform 3, isoform 4 and isoform 5 can interact with the extracellular domain of the receptor. (Microbial infection) Interacts with adenovirus subgroups A, C, D, E and F fiber proteins as well as coxsackievirus B1, B2, B3, B4, B5 and B6 capsid proteins (PubMed:14978041, PubMed:9733828, PubMed:10666333, PubMed:10814575, PubMed:12297051, PubMed:10567268).
Molecular function
Host cell receptor for virus entry, Receptor
More Types Infomation
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC
-
- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ELISA, IHC-P
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IF, FC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ICC, IF, IHC
-
- Species Reactivity: Human
- Type: Mouse IgG2b, κ
- Application: FuncS
-
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, FC, FuncS
- Human Anti-CXADR Recombinant Antibody (VS-0723-WK60) (VS-0723-WK60)
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- Derivation: Chimeric (rabbit/human)
- Species Reactivity: Human
- Type: Chimeric (rabbit/human) IgG1
- Application: FC
- Chicken Anti-CAR Polyclonal IgY (BRD-0865MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
- Mouse Anti-CXADR Recombinant Antibody; Fab Fragment (TAB-096MZ-F(E)) (TAB-096MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
- Mouse Anti-CXADR Recombinant Antibody; Fab Fragment (TAB-095MZ-F(E)) (TAB-095MZ-F(E))
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- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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For Research Use Only. Not For Clinical Use.