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CDH5

CDH5 (Cadherin 5) is a Protein Coding gene. Diseases associated with CDH5 include Periapical Granuloma and Epithelioid Sarcoma. Among its related pathways are ERK Signaling and RET signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and ion channel binding.
Protein class

Cancer-related genes, CD markers, Plasma proteins

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Adipocytes, Endothelial cells, Hepatic stellate cells, Late spermatids, Syncytiotrophoblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (HUVEC TERT2, TIME)

Interaction

Interacts (via cadherin 5 domain) with PTPRB (By similarity). Interacts with TRPC4 (PubMed:19996314). Interacts with KRIT1 (PubMed:20332120). Interacts with PARD3 (By similarity). Interacts with RTN4 (isoform B) (PubMed:21183689). Interacts with PALS1; the interaction promotes PALS1 localization to cell junctions and is required for CDH5-mediated vascular lumen formation and endothelial cell (PubMed:27466317).

More Types Infomation

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