Secreted
Cell type enhanced (Prostatic glandular cells, Basal prostatic cells, Endometrial stromal cells, Urothelial cells, Pancreatic endocrine cells)
Not detected in immune cells
Cell line enhanced (BJ, BJ hTERT+, CACO-2, fHDF/TERT166)
Interacts with LRP6 (PubMed:11448771, PubMed:17804805, PubMed:20093360, PubMed:22000856). Interacts (via the C-termianl Cys-rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt-mediated signaling (PubMed:19746449). Forms a ternary complex with LRP6 and KREM1 (PubMed:27524201). Interacts with KREM1 (PubMed:17804805).
Developmental protein
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For Research Use Only. Not For Clinical Use.