Disease related genes, Human disease related genes
Membrane
Group enriched (Alveolar cells type 1, Suprabasal keratinocytes)
Low immune cell specificity
Cell line enhanced (MCF7, RT4, SK-BR-3, T-47d)
Interacts with PTK2; regulates PTK2 activation and localization (PubMed:19494199, 21637765). Interacts with ITGB3; regulates the levels of the heterodimer ITGA5-ITGB3 integrin surface expression (PubMed:16216233). Interacts with P2RX7 (via C-terminus) (PubMed:12107182). Interacts with ITGB1; the interaction may be direct or indirect and ITGB1 has a heterodimer form.
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For Research Use Only. Not For Clinical Use.