Loading...
F2
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants.
Protein class
Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5. In plasma, interacts (via N-terminus) with alpha-1-microglobulin with molar ratio 1:2 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin.
Molecular function
Hydrolase, Protease, Serine protease
More Types Infomation
-
- Species Reactivity: Human
- Type: Human Fab
- Application: WB, IF, FuncS
-
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB, FuncS
- Recombinant Anti-human F2 Antibody scFv Fragment (MOB-344-S(P))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, ELISA, FuncS
- Recombinant Human Anti-human F2 Antibody Fab Fragment (MHH-344-F(E))
-
- Derivation: Human
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, WB, Dot, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IP, RIA, WB
-
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, FuncS
- Recombinant Human Anti-human F2 Antibody scFv Fragment (MHH-344-S(P))
-
- Derivation: Human
- Species Reactivity: Human
- Type: scFv
- Application: FC, WB, FuncS
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: RIA, WB, ELISA
-
- Species Reactivity: Human
- Type: Human IgG
- Application: WB, IF, FuncS
- Recombinant Human Anti-human F2 Antibody (MHH-344)
-
- Derivation: Human
- Species Reactivity: Human
- Type: IgG
- Application: Neut, IF, FuncS
-
- Species Reactivity: Human
- Type: Human scFv
- Application: WB, IF, FuncS
-
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FuncS
- Recombinant Anti-human F2 Antibody Fab Fragment (MOB-344-F(E))
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, IP, FuncS
- Recombinant Anti-human F2 Antibody (MOB-344)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, Dot, FuncS
- Mouse Anti-F2 Recombinant Antibody (clone 513) (NEUT-760CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, Inhib, WB
- Mouse Anti-F2 Recombinant Antibody (clone 5020) (NEUT-761CQ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, Inhib
- Human Anti-F2 Antibody (clone YC049), mRNA (PABL-092-mRNA)
-
- Species Reactivity: Human
- Human Anti-F2 Antibody (clone YC050), mRNA (PABL-469-mRNA)
-
- Species Reactivity: Human
- Mouse Anti-F2 Recombinant Antibody (clone aTM-1); scFv Fragment (HPAB-0050-YC-S(P))
-
- Derivation: Phage display library
- Species Reactivity: Human, Monkey
- Type: Mouse scFv
- Application: ELISA
- Human Anti-F2 Recombinant Antibody (clone h1601-008); scFv Fragment (HPAB-0049-YC-S(P))
-
- Derivation: Humanized
- Species Reactivity: Human, Monkey
- Type: Humanized scFv
- Application: ELISA
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.