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F2RL1

The anti-PAR-2 antibodies can be used for treatment of pain, including post-operative incision pain, neuropathic pain, fracture pain, osteroporotic fracture pain, bone cancer pain or gout joint pain; inflammatory pain associated with irritable bowel syndrome; and inflammation related to rheumatoid arthritis or osteoarthritis.
Protein class

G-protein coupled receptors, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Suprabasal keratinocytes, Distal enterocytes, Urothelial cells, Basal keratinocytes, Paneth cells, Glandular and luminal cells, Gastric mucus-secreting cells)

Immune cell specificity

Immune cell enhanced (neutrophil)

Cell line specificity

Cell line enhanced (PC-3, RPTEC TERT1)

Interaction

Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14 (By similarity).

Molecular function

G-protein coupled receptor, Receptor, Transducer

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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